Endocannabinoids Attenuate the Virulence of Certain Enteropathogenic Bacteria. Issue 3 (March 2021)

• Record Type: Journal Article
• Authors: Osman, Marwan; Papon, Nicolas; Weill, François-Xavier
• Is Part Of: Trends in microbiology. Volume 29:Issue 3(2021)
• Page Start: 185
• Page End: 187
• Publication Date: 2021-03
• Subjects: endocannabinoids -- 2-arachidonoyl glycerol -- QseC histidine kinase -- enteric infections; Microbiology -- Periodicals; Infection -- Periodicals; Virulence (Microbiology) -- Periodicals; Infection -- Periodicals; Microbiology -- Periodicals; Virulence -- Periodicals; Microbiologie -- Périodiques; Infection -- Périodiques; Virulence (Microbiologie) -- Périodiques; Infection; Microbiology; Virulence (Microbiology); 579
• DOI: 10.1016/j.tim.2020.12.008
• Languages: English
• ISSNs: 0966-842X

Abstract

Abstract : The mammalian endocannabinoid system modulates gastrointestinal physiology and immunity via lipid hormones (endocannabinoids). Ellermann et al . have recently revealed the effect of the endocannabinoid, 2-arachidonoyl glycerol (2-AG) on intestinal infection. They show that 2-AG directly modulates bacterial function by antagonizing the provirulence receptor QseC, thereby protecting mice against enteric infection. The endocannabinoid system has already been identified as a promising target in the treatment of inflammatory bowel diseases, but these new findings raise questions about the possible benefits of using cannabinoids to treat intestinal bacterial infections.