What NIR photodynamic activation offers molecular targeted nanomedicines: Perspectives into the conundrum of tumor specificity and selectivity. (February 2021)

• Record Type: Journal Article
• Authors: Bhandari, Chanda; Guirguis, Mina; Savan, N. Anna; Shrivastava, Navadeep; Oliveira, Sabrina; Hasan, Tayyaba; Obaid, Girgis
• Is Part Of: Nano today. Volume 36(2021)
• Publication Date: 2021-02
• Subjects: AlPcS4 Aluminum phthalocyanine tetra sulfate -- AUC Area Under Curve -- BP Bispyrene -- CA Cholic Acid -- CD Carbon nanodots -- Ce6 Chlorine e6 -- Cet-PIN Cetuximab Photoimmunonanoconjugate -- EGFR Epidermal Growth Factor Receptor -- EPR Enhanced Permeability and Retention (effect) -- FA Folic Acid -- FDG 2′-deoxy-2′-(18F) fluoro-D-glucose -- FR Folic Acid Receptor -- HANP Hyaluronic Acid Nanoparticles -- HER-2 Human Epidermal Growth Factor Receptor-2 -- IC50 Half Maximal Inhibitory Concentration -- ICGD Indocyanine Green Derivatives -- IgG Immunoglobulin G -- LTN Ligand Targeted Nanomedicines -- mt-PNM Molecular Targeted Photonanomedicines -- MPS Mononuclear Phagocytic System -- NMOF Nanoscale Metal Organic Framework -- OAUCNP Oleic Acid Upconversion Nanoparticles -- PDT Photodynamic Therapy -- PDX Patient-Derived Xenograft -- PEG Polyethylene Glycol -- PIC Photoimmunonanoconjugates -- PS Photosensitizer -- PSMA Prostate Specific Membrane Antigen -- PTK7 Protein Tyrosine Kinase -- RMS Reactive Molecular Species -- TAM Tumor Associated Macrophages -- ZnPC Zinc(II)phthalocyanine; Photodynamic therapy -- Photonanomedicines -- Specificity -- Selectivity -- Solid tumors; Nanotechnology -- Periodicals; Nanosciences -- Périodiques; 620.505
• DOI: 10.1016/j.nantod.2020.101052
• Languages: English
• ISSNs: 1748-0132

Abstract

Abstract: Near infrared (NIR) photodynamic activation is playing increasingly critical roles in cutting-edge anti-cancer nanomedicines, which include spatiotemporal control over induction of therapy, photodynamic priming, and phototriggered immunotherapy. Molecular targeted photonanomedicines (mt-PNMs) are tumor-specific nanoscale drug delivery systems, which capitalize on the unparalleled spatio-temporal precision of NIR photodynamic activation to augment the accuracy of tumor tissue treatment. mt-PNMs are emerging as a paradigm approach for the targeted treatment of solid tumors, yet remain highly complex and multifaceted. While ligand targeted nanomedicines in general suffer from interdependent challenges in biophysics, surface chemistry and nanotechnology, mt-PNMs provide distinct opportunities to synergistically potentiate the effects of ligand targeting. This review provides what we believe to be a much-need demarcation between the processes involved in tumor specificity (biomolecular recognition events) and tumor selectivity (preferential tumor accumulation) of ligand targeted nanomedicines, such as mt-PNMs, and elaborate on what NIR photodynamic activation has to offer. We discuss the interplay between both tumor specificity and tumor selectivity and the degree to which both may play central roles in cutting-edge NIR photoactivable nanotechnologies. A special emphasis is made on NIR photoactivable biomimetic nanotechnologies that capitalize on both specificity and selectivity phenomena to augment the safety and efficacy of photodynamic anti-tumor regimens. Graphical Abstract: ga1 Highlights: NIR photodynamicactivation offers molecular targeted photonanomedicines (mt-PNMs) unique advantages. mt-PNM efficacy is due to target recognition (specificity) in addition to the preferential tumor accumulation (selectivity). Tumor selectivity and tumor specificity of mt-PNMs are two interdependent, yet distinct phenomena. The distinction and interdependence of selectivity and specificity for tumor photodestruction are presented in this review.