Magnetic bioactive glasses/Cisplatin loaded-chitosan (CS)-grafted- poly (ε-caprolactone) nanofibers against bone cancer treatment. (15th April 2021)

• Record Type: Journal Article
• Authors: Amini, Zahra; Rudsary, Sam Shekofte; Shahraeini, Seyed Sadegh; Dizaji, Babak Faraji; Goleij, Pouya; Bakhtiari, Ameneh; Irani, Mohammad; Sharifianjazi, Fariborz
• Is Part Of: Carbohydrate polymers. Volume 258(2021)
• Publication Date: 2021-04-15
• Subjects: Magnetic bioactive glasses -- Nanofiber -- Cisplatin -- Drug release -- Bone cancer; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2021.117680
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Chitosan-grafted- Poly (ε-caprolactone) nanofibers were synthesized via electrospinning. Magnetic bioactive glasses (MBGs)/Cisplatin were doped into nanofibers. The performance of nanofibers was studied against MG-63 osteosarcoma cells. The controlled release of Cisplatin without burst release was obtained. 100 μg/mL nanofibers was optimum to kill MG-63 cells via chemotherapy/hyperthermia. Abstract: The bioactive glasses (BGs)/Cisplatin and magnetic bioactive glasses (MBGs)/Cisplatin were doped into the chitosan (CS)-grafted- poly (ε-caprolactone) (PCL) nanofibers for controlled release of Cisplatin under various pH values and temperatures. The simultaneous effect of chemotherapy and hyperthermia was investigated against MG-63 osteosarcoma cells by treating of cells with Cs-g-PCL/MBGs/Cisplatin under an alternating magnetic field. The synthesized nanofibers were characterized using XRD, FTIR, 1 H NMR, SEM, and EDX analysis. The bioactivity, and drug loading efficiency of fibers were investigated. There was no initial burst release of Cisplatin from BGs/Cisplatin and MBGs/Cisplatin loaded Cs-g-PCL/MBGs nanofibers and the Cisplatin release rate was accelerated under pH of 5.5 and temperature of 43 °C compared with physiological condition. The apoptotic/necrotic effect indicated that 100 μg mL −1 nanofibers was optimum for killing of MG-63 cells. The future researches could be focused on the application of nanofibers as an implantable device next to a bone tumor for bone cancer therapy in vivo.