Redefining prophylaxis in the modern era. (29th May 2020)

• Record Type: Journal Article
• Authors: Mahlangu, Johnny N.; Blanchette, Victor; Klamroth, Robert
• Is Part Of: Haemophilia. Volume 27(2021)Supplement 3
• Page Start: 21
• Page End: 27
• Publication Date: 2020-05-29
• Subjects: modern era -- novel therapies -- prophylaxis -- redefinition -- steady‐state -- trough levels; Hemophilia -- Periodicals; 616.1572005
• DOI: 10.1111/hae.14035
• Languages: English
• ISSNs: 1351-8216

Abstract

Abstract: Prophylaxis is the globally accepted standard of care for persons with haemophilia and presents many advantages over episodic treatment. The prophylaxis benefits include bleed reduction, reduction in musculoskeletal complications and improvement in the quality of life. The currently evolving novel therapies for the management of haemophilia has ushered a new era characterized by improved prophylaxis targets and outcomes. These redefined targets and outcomes have necessitated the need to also redefine prophylaxis. In this state‐of‐the‐art review, we redefine prophylaxis in the modern era by revisiting its definition, presenting data to support higher trough levels to achieve with prophylaxis and introducing steady‐state haemostasis as a possible new target for prophylaxis.