Genetic characterization of acute myeloid leukemia patients with mutations in IDH1/2 genes. (February 2021)

• Record Type: Journal Article
• Authors: Acha, Pamela; Hoyos, Montserrat; Pratcorona, Marta; Fuster-Tormo, Francisco; Palomo, Laura; Ortega, Esther; Zamora, Lurdes; Vives, Susana; Granada, Isabel; Montoro, Julia; Garcia, Antoni; Arnan, Montserrat; Cervera, Marta; Canet, Marta; Gallardo, David; Arenillas, Leonor; Esteve, Jordi; Baragay, Joan; Salamero, Olga; Motlló, Cristina; Ortín, Xavier; Sierra, Jordi; Solé, Francesc
• Is Part Of: Leukemia research. Volume 101(2021)
• Publication Date: 2021-02
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2020.106492
• Languages: English
• ISSNs: 0145-2126

Abstract

Highlights: IDH1/2 cases account for 23% of the studied cohort. Mutual exclusivity was confirmed for IDH1 and IDH2 mutations. IDH1 (86%) and IDH2 (89%) mutations frequently constitute an ancestral event.