Dietary fat content and adipose triglyceride lipase and hormone-sensitive lipase gene expressions in adults' subcutaneous and visceral fat tissues. (February 2021)

• Record Type: Journal Article
• Authors: Zareie, Rahim; Yuzbashian, Emad; Rahimi, Hamed; Asghari, Golaleh; Zarkesh, Maryam; Hedayati, Mehdi; Djazayery, Abolghassem; Movahedi, Ariyo; Mirmiran, Parvin; Khalaj, Alireza
• Is Part Of: Prostaglandins, leukotrienes, and essential fatty acids. Volume 165(2021)
• Publication Date: 2021-02
• Subjects: Adipose triglyceride lipase -- Hormone-sensitive lipase -- Adipose tissue -- Gene expression -- Dietary fat quantity -- Dietary fat composition; Lipids -- Periodicals; Unsaturated fatty acids -- Periodicals; Prostaglandins -- Periodicals; Leukotrienes -- Periodicals; Fatty Acids, Unsaturated -- Periodicals; Acides gras insaturés -- Périodiques; Prostaglandines -- Périodiques; Leucotriènes -- Périodiques; Lipides -- Périodiques; 612.01577
• DOI: 10.1016/j.plefa.2021.102244
• Languages: English
• ISSNs: 0952-3278

Abstract

Highlights: Fat intake positively associated with ATGL gene expression. Fat intake inversely associated with HSL gene expression. Myristic, palmitic, and oleic acid positively associated with ATGL mRNA levels. Myristic, palmitic, and oleic acid negatively associated with HSL mRNA levels. No associations found in visceral adipose tissue or obese participants. Abstract: Introduction: We examined the association of adipose triglyceride lipase (ATGL) and hormone-sensitive lipase ( HSL) gene expressions, as the key regulators of lipolysis, with dietary fat quantity and composition in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). Methods: In this observational study, samples were collected from patients undergoing elective abdominal surgery. Participants were categorized into two groups based on their body mass index (BMI) status. Dietary, anthropometric, and biochemical data were collected before surgery. Linear regression was performed to determine the association of dietary fat content with ATGL and HSL gene expressions in SAT and VAT. Results: 152 individuals with a mean ± SD age of 40.7 ± 13.2 years and a median (inter-quartile range) BMI of 39.4 (26.5–45.3 kg/m 2 ) participated in this study, of whom 54 were non-obese (BMI<30 kg/m 2 ), and 98 were obese (BMI≥30 kg/m 2 ). Among non-obese participants, positive associations were observed between ATGL mRNA expression and reported intakes of total fatty acids (TFA) (β=0.306, P = 0.025), myristic (β=0.285, P = 0.038), palmitic (β=0.417, P = 0.002), oleic (β=0.333, P = 0.017), dairy trans (β=0.374, P = 0.006), and other trans FAs (β=0.369, P = 0.006) in SAT. In contrast, inverse associations between HSL mRNA expression and reported intakes of TFAs (β=-0.377, P = 0.005), myristic (β=-0.282, P = 0.039), palmitic (β=-0.372, P = 0.006), stearic (β=-0.314, P = 0.020), and oleic acid (β=-0.372, P = 0.007) were observed in SAT. No associations were observed among obese participants, nor in VAT among non-obese individuals. Conclusion: ATGL and HSL mRNA expressions in SAT were associated with dietary fat quantity and composition among non-obese adults.