MicroRNAs: Emerging oncogenic and tumor-suppressive regulators, biomarkers and therapeutic targets in lung cancer. (1st April 2021)

• Record Type: Journal Article
• Authors: Tang, Shengjie; Li, Shuangjiang; Liu, Tao; He, Yiwei; Hu, Haiyang; Zhu, Yunhe; Tang, Shoujun; Zhou, Haining
• Is Part Of: Cancer letters. Volume 502(2021)
• Page Start: 71
• Page End: 83
• Publication Date: 2021-04-01
• Subjects: MicroRNAs -- Lung cancer -- Cell proliferation -- Apoptosis -- Metastasis -- Epithelial to mesenchymal transition -- Biomarkers -- Therapeutic targets; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2020.12.040
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: Lung cancer is one of the most common solid tumors worldwide and the leading cause of cancer-related deaths, causing a devastating impact on human health. The clinical prognosis of lung cancer is usually restricted by delayed diagnosis and resistance to anticancer therapies. MicroRNAs, a range of small endogenous noncoding RNAs 22 nucleotides in length, have emerged as one of the most important players in cancer initiation and progression in recent decades. Current evidence reveals pivotal roles of microRNAs in regulating cell proliferation, migration, invasion and metastasis in lung cancer. An increasing number of preclinical and clinical studies have also explored the potential of microRNAs as promising biomarkers and new therapeutic targets for lung cancer. The current review summarizes the most recent progress on the functional mechanisms of microRNAs involved in lung cancer development and progression and further discusses the clinical application of miRNAs as putative therapeutic targets for molecular diagnosis and prognostic prediction in lung cancer. Highlights: Comprehensive review on biological and clinical implications of miRNAs in lung cancer. Current progress on molecular mechanisms of miRNAs involved in lung cancer development and progression. Diagnostic and prognostic significance of miRNAs in lung cancer. MiRNAs as putative therapeutic targets in lung cancer.