Probiotics treatment improves cognitive impairment in patients and animals: A systematic review and meta-analysis. (January 2021)

• Record Type: Journal Article
• Authors: Lv, Tingting; Ye, Mengfei; Luo, Fangyi; Hu, Baiqi; Wang, Anzhe; Chen, Jiaqi; Yan, Junwei; He, Ziyi; Chen, Feng; Qian, Chao; Zhang, Jian; Liu, Zheng; Ding, Zhinan
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 120(2021)
• Page Start: 159
• Page End: 172
• Publication Date: 2021-01
• Subjects: 5-HT serotonin -- CORT corticosterone -- HPA hypothalamic–pituitary–adrenal -- NE noradrenaline -- ELC early learning composite -- IDO indoleamine 2, 3-dioxygenase -- AD Alzheimer's disease patients -- APT Attention and Perceptivity Test -- BB94 Bifidobacterium B94 -- BDNF brain derived neurotrophic factor -- BDT Block Design Test -- CFU colony forming units -- CVLT California Verbal Learning Test -- DST Digit Symbol Test -- Ecologic® Barrier+4 Ecologic® Barrier+B.breve W25, +B.longum W108+L. helveticus W74+L. rhamnosus W71 -- Cafcafeteria diet -- Ecologic®Barrier=B.bifidumW23+B.lactis W51+B.lactis W52+L.acidophilus W37+L.brevis W63+L.casei W56+L. salivarius W24+Lc.lactis W19+Lc.lactis W58 -- FMS fibromyalgia -- GABA gamma-aminobutyric acid -- GF germ-free -- HA hyperammonemia -- HFD high-fat diet -- IGT the Iowa gambling task scores -- L.327 Lactobacillus casei subsp.casei 327 -- L.GG Lactobacillus GG -- L.K71 Lactobacillus paracasei K71 -- LP Lactobacillus Plantarum -- MDD major depressive disorder patients -- MHE minimal hepatic encephalopathy patients -- MMSE Mini-mental state examination -- MS Multiple Sclerosis(MS)model -- MWM Morris water maze tests -- ND normal diet -- NR not reported -- ORT Object Recognition Test -- PAT Passive Avoidance Test -- Pro probiotic -- RCT randomized controlled trials -- SAMP8 senescence-accelerated mouse prone 8 model -- SMD standardised mean difference -- SSRI selective serotonin reuptake inhibitors -- TYM Test Your Memory -- UCMS unpredictable chronic mild stress -- USA United States of America -- VSL#3 B. longum DSM 24736+B. infantis DSM 24737+B. breve DSM 24732+L. acidophilus DSM 24735+L. paracasei DSM 24733+L. bulgaricus DSM 24734+L. plantarum DSM 24730+ Streptococcus salivarius subspecies thermophilus DSM 24731; Probiotics -- Cognitive function -- Therapy -- Meta-analysis -- Morris water maze test -- Novel-object recognition test; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2020.10.027
• Languages: English
• ISSNs: 0149-7634

Abstract

Highlights: A meta-analysis of probiotic intervention for cognitive function in humans and animals. The effects on cognitively impaired individuals were greater than healthy individuals. The therapeutic effect of one strain of probiotic supplement was greater than multiple probiotics in humans. Probiotics were effective therapy for improving cognition in cognitively impaired patients. We provide some suggestions for probiotics intervention and tend to support a customized approach for different individuals. Abstract: The gut–brain axis has received considerable attention in recent years, and the "psychobiotics" concept indicates that probiotics have a potential positive effect on cognitive function. Therefore, the aim of this study was to quantitatively evaluate the influence of probiotics on cognition. We conducted a random-eff ;ects meta-analysis of 7 controlled clinical trials and 11 animals studies to evaluate the eff ;ects of probiotics on cognitive function. Probiotics supplementation enhanced cognitive function in both human (0.24 [0.05–0.42]; I 2 = 0 %) and animal studies (0.90 [0.47–1.34]; I 2 = 74 %). Subgroup analyses indicated that the effects of probiotics on cognitively impaired individuals (0.25 [0.05–0.45]; I 2 = 0 %) were greater than those on healthy ones (0.15 [−0.30 to 0.60]; I 2 = 0 %). Furthermore, compared with a multiple-probiotic supplement, a single strain of probiotics was more effective in humans. The meta-analysis provided some suggestions for probiotics intervention and tended to support a customized approach for different individuals to ameliorate cognitive disorders. Future additional clinical trials are necessary to evaluate therapeutic effect and influencing factors.