Characteristics and outcome of multiple myeloma patients presenting with anaemia only: A retrospective multi-centre study. (February 2021)

• Record Type: Journal Article
• Authors: Shragai, Tamir; Gatt, Moshe E.; Shaulov, Adir; Katodritou, Eirini; Triantafyllou, Theodora; Lavi, Noa; Pouli, Anastasia; Sioni, Anastasia; Vaxman, Iuliana; Zektser, Miri; Ganzel, Chezi; Benyamini, Noam; Trestman, Svetlana; Ziv-Baran, Tomer; Adam, Yasmin; Cohen, Yael C.; Avivi, Irit
• Is Part Of: Leukemia research. Volume 101(2021)
• Publication Date: 2021-02
• Subjects: Myeloma -- Anemia; Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2020.106498
• Languages: English
• ISSNs: 0145-2126

Abstract

Highlights: Patients with Multiple myeloma presetting with anaemia only are rare. Anaemia-only MM patients have higher degree of bone marrow plasmacytosis. Anaemia-only MM patients showed lower rates of deep responses to induction therapy. Anaemia-only MM patients represents a unique, potentially less favorable population. Abstract: Background: Multiple myeloma (MM) patients presenting with anaemia as their sole clinical manifestation are rare and not fully defined. Methods: Retrospective multi-site study comparing the characteristics and outcome of MM patients with anaemia only with matched patients, presenting with multi-organ disease. Results: Anaemia-only patients had a higher percentage of bone marrow monoclonal plasma cells group (median 60% [IQR 42−80%] vs. 37% [IQR 17–65%], respectively; p < 0.001), and a lower responsiveness to treatment (≥VGPR rates were 54% vs 74%, p = 0.049). Median survival in anaemia only patients was 65.9 ± 6.9 vs 83.4 ± 8.8 months in matched control patients (P = n.s). Conclusions: MM patients presenting with anaemia only represents a unique, potentially less favorable population.