Catalytic evaluation of biocompatible chitosan-stabilized gold nanoparticles on oxidation of morin. (15th April 2021)

• Record Type: Journal Article
• Authors: Bulut, Onur; Yilmaz, M. Deniz
• Is Part Of: Carbohydrate polymers. Volume 258(2021)
• Publication Date: 2021-04-15
• Subjects: Chitosan -- Gold nanoparticles -- Morin -- Oxidation -- Catalysis; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2021.117699
• Languages: English
• ISSNs: 0144-8617

Abstract

Graphical abstract: Highlights: Chitosan-stabilized gold nanoparticles (CH-AuNPs) were prepared and characterized. The catalytic activity of CH-AuNPs was investigated using the oxidation of morin. The long-term stability and reusability of CH-AuNPs were evaluated. Cytotoxicity studies show that CH-AuNPs are biocompatible with HeLa and MCF-7 cells. Abstract: Herein, we present a study on the catalytic evaluation of biocompatible chitosan-stabilized gold nanoparticles ( CH-AuNPs) on the oxidation of morin as a model reaction. Biocompatible CH-AuNPs have been characterized through several analytical methods such as TEM, UV–vis, DLS and zeta potential analyses. CH-AuNPs have a small size (10 ± 0.4 nm) with a narrow size distribution and high positive surface charge (+40.1 mV). CH-AuNPs has been demonstrated to be highly active nanocatalysts for the oxidation of morin with the assistance of H2 O2 as an oxidant compared with control experiments. The oxidation reaction follows a pseudo-first-order reaction. The kinetic studies show that apparent rate constant (kapp ) is positively correlated with the concentrations of CH-AuNPs and H2 O2, while it is negatively correlated with morin concentration. Furthermore, the reusability tests have been performed and the results demonstrate the long-term stability and reusability of CH-AuNPs without any loss of catalytic activity. Cytotoxicity studies exhibit that CH-AuNPs have low toxicity and they are biocompatible with HeLa and MCF-7 cells.