Bioaccumulation and toxicokinetics of zinc oxide nanoparticles (ZnO NPs) co-exposed with graphene nanosheets (GNs) in the blackfish (Capoeta fusca). (April 2021)

• Record Type: Journal Article
• Authors: Sayadi, Mohammad Hossein; Pavlaki, Maria D.; Martins, Roberto; Mansouri, Borhan; Tyler, Charles R.; Kharkan, Javad; Shekari, Hossein
• Is Part Of: Chemosphere. Volume 269(2021)
• Publication Date: 2021-04
• Subjects: Uptake rate -- Elimination rate -- Combined exposure -- Intestine -- Kidney -- Liver; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2020.128689
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: In this study, we investigated the bioaccumulation and toxicokinetics of zinc oxide nanoparticles (ZnO NPs) alone and in the presence of graphene nanosheets (GNs) in the blackfish ( Capoeta fusca ). Blackfish were exposed via water to two ZnO NPs concentrations alone or as a combination with GNs and uptake of Zn into the gills, intestine, liver, and kidney was assessed at 7, 14 and 28 d. Zn elimination from these tissues was then assessed after a further 7, 14 and 28 d in clean water for both ZnO NPs concentrations and combined ZnO NPs/GN exposures. In the body tissues analyzed of exposed fish, the highest amounts of Zn occurred in the intestine and the lowest amount in the liver. Zn levels in blackfish after 28 d of exposure were higher in all treatment groups compared to those on 7 d ( p < 0.05). For both ZnO NPs exposure concentrations, the highest amount of Zn was eliminated from the intestine, followed by the gills. Furthermore, elimination kinetics for both ZnO NPs concentrations alone and in combination with GNs showed that the shortest half-life for Zn is occurring in the intestine. Moreover, uptake rates of Zn in fish exposed to ZnO NPs + GNs followed the same pattern observed for the ZnO NP, with intestine and gills having the highest levels followed by kidney and liver. Thus, we show accumulation and elimination of Zn from ZnO NPs in blackfish depends on the tissue, exposure concentration and duration, and is dependent on the presence of GNs. Graphical abstract: Image 1 Highlights: The highest and lowest amount of Zn in tissue occurred in the intestine and liver, respectively. Zn elimination occurred more readily in the intestine compared to the rest of the tissues analyzed. Co-exposure of ZnO NPs with GNs decreased the accumulation of Zn.