Epigenetic Memories: The Hidden Drivers of Bacterial Persistence?. Issue 3 (March 2021)

• Record Type: Journal Article
• Authors: Riber, Leise; Hansen, Lars Hestbjerg
• Is Part Of: Trends in microbiology. Volume 29:Issue 3(2021)
• Page Start: 190
• Page End: 194
• Publication Date: 2021-03
• Subjects: epigenetic inheritance -- bacterial persistence -- DNA methylation -- gene expression regulation -- SMRT sequencing -- nanopore sequencing; Microbiology -- Periodicals; Infection -- Periodicals; Virulence (Microbiology) -- Periodicals; Infection -- Periodicals; Microbiology -- Periodicals; Virulence -- Periodicals; Microbiologie -- Périodiques; Infection -- Périodiques; Virulence (Microbiologie) -- Périodiques; Infection; Microbiology; Virulence (Microbiology); 579
• DOI: 10.1016/j.tim.2020.12.005
• Languages: English
• ISSNs: 0966-842X

Abstract

Abstract : Epigenetic modifications, including DNA methylation, stably alter gene expression without modifying genomic sequences. Recent evidence suggests that epigenetic regulation coupled with a long-term 'memory' effect plays a major role within bacterial persistence formation. Today, emerging high-resolution, single-molecule sequencing technologies allow an increased focus on DNA modifications as regulatory epigenetic marks, which presents a unique opportunity to identify possible epigenetic drivers of bacterial persistence.