An observational study on Ca supplementation and dietary intake during pregnancy on low birth weight and small for gestational age. Issue 4 (4th March 2021)

• Record Type: Journal Article
• Authors: Dai, Wei; Deng, Xiaohui; Li, Lanlan; Qiu, Jie; Mao, Baohong; Shao, Yawen; Xu, Sijuan; Yang, Tao; He, Xiaochun; Cui, Hongmei; Lin, Xiaojuan; Lv, Ling; Tang, Zhongfeng; Liu, Qing
• Is Part Of: Public health nutrition. Volume 24:Issue 4(2021)
• Page Start: 622
• Page End: 631
• Publication Date: 2021-03-04
• Subjects: Ca supplementation, -- Dietary Ca intake, -- Low birth weight, -- Small for gestational age, -- Infant; Nutrition -- Periodicals; Nutrition policy -- Periodicals; Public health -- Periodicals; 613.2
• DOI: 10.1017/S1368980020004425
• Languages: English
• ISSNs: 1368-9800

Abstract

Abstract: Objective: To evaluate the effects of dietary Ca intake and Ca supplementation during pregnancy on low birth weight (LBW) and small for gestational age (SGA) infants. Design: A birth cohort study was conducted in 2010–2012 at the Gansu Provincial Maternity and Child Care Hospital in Lanzhou, China. Setting: A birth cohort study. Participants: Totally, 9595 pregnant women who came to the hospital for delivery at 20 weeks of gestation or more, and who were 18 years of age or older. Results: Compared with non-users, Ca supplement users had a reduced risk of LBW infants (OR = 0·77, 95 % CI: 0·63, 0·95) and a reduced risk of nulliparous women giving birth to LBW infants (OR = 0·75, 95 % CI: 0·58, 0·98) ( P < 0·05). More specifically, both the use of Ca supplement before conception and during pregnancy (OR = 0·44, 95 % CI: 0·19, 0·99) and during pregnancy only (OR = 0·80, 95 % CI: 0·65, 0·99) had the main effect of reducing risk of nulliparous women giving birth to LBW infants ( P < 0·05). There was no association between Ca supplementation and SGA (OR = 0·87, 95 % CI: 0·75, 1·01) ( P > 0·05). However, higher dietary Ca intake during pregnancy decreases the risk of both LBW (quartile 2: OR = 0·72, 95 % CI: 0·55, 0·94; quartile 3: OR = 0·68, 95 % CI: 0·50, 0·62) and SGA infants (quartile 2: OR = 0·77, 95 % CI: 0·63, 0·95; quartile 3: OR = 0·71, 95 % CI: 0·57, 0·88, quartile 4: OR = 0·71, 95 % CI: 0·57, 0·88) ( P < 0·05). Conclusions: Ca supplementation and adequate dietary intake of Ca during pregnancy are associated with a decreased risk of LBW infants born to nulliparous women.