Chromophore‐Free Sealing and Repair of Soft Tissues Using Mid‐Infrared Light‐Activated Biosealants. (2nd November 2020)

• Record Type: Journal Article
• Authors: Ridha, Inam; Basiri, Ali; Godeshala, Sudhakar; Rafique, Md Zubair Ebne; Ghosh, Deepanjan; Williams, Jason; Chawla, Nikhilesh; Lee, Jung Keun; Kilbourne, Jacquelyn; Yao, Yu; Rege, Kaushal
• Is Part Of: Advanced functional materials. Volume 31:Number 6(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-11-02
• Subjects: laser sealing -- tissue sealing -- surgical devices -- surgical sealant; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202007811
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Poor strength, infection, leakage, long procedure times, and inflammation limit the efficacy of common tissue sealing devices in surgeries and trauma. Light‐activated sealing is attractive for tissue sealing and repair, and can be facilitated by the generation of local heat following absorption of nonionizing laser energy by chromophores. Here, the inherent ability of biomaterials is exploited to absorb nonionizing, mid‐infrared (midIR) light in order to engender rapid photothermal sealing and repair of soft tissue wounds. In this approach, the biomaterial simultaneously acts as a photothermal convertor as well as a biosealant, which dispenses the need for exogeneous light‐absorbing nanoparticles or dyes. Biomechanical recovery, mathematical modeling, histopathology analyses, tissue strain mapping using digital imaging correlation, and visualization of the biosealant‐tissue interface using hyperspectral imaging indicate superior performance of midIR sealing in live mice compared to conventional sutures and glue. The midIR‐biosealant approach demonstrates rapid sealing of soft tissues, improves cosmesis, lowers potential for scarring, obviates safety concerns because of the nonionizing light used, and allows adoption of a wide diversity of biomaterials. Taken together, the studies demonstrate a novel advance both in biomaterials for surgical sealing along with the use of nonionizing midIR light, with high potential for clinical translation. Abstract : The simultaneous absorption of mid‐infrared (midIR) laser energy and concomitant conversion to heat by biosealants resulting in the rapid sealing of soft tissues is described. The use of nonionizing midIR light leads to efficacious tissue sealing, improves cosmesis, lowers propensity for scarring, dispenses the use of chromophores, and allows for the use of a wide diversity of biomaterials as light‐activated sealants for tissue repair.