Nitric Oxide‐Driven Nanomotor for Deep Tissue Penetration and Multidrug Resistance Reversal in Cancer Therapy. Issue 3 (18th December 2020)

• Record Type: Journal Article
• Authors: Wan, Mi Mi; Chen, Huan; Da Wang, Zhong; Liu, Zhi Yong; Yu, Yue Qi; Li, Lin; Miao, Zhuo Yue; Wang, Xing Wen; Wang, Qi; Mao, Chun; Shen, Jian; Wei, Jia
• Is Part Of: Advanced science. Volume 8:Issue 3(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-12-18
• Subjects: cancer therapy -- deep‐penetration -- degradation of tumor extracellular matrix -- multidrug resistance -- nanomotors -- nitric oxide; Science -- Periodicals; 505
• DOI: 10.1002/advs.202002525
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract: Poor permeation of therapeutic agents and multidrug resistance (MDR) in solid tumors are the two major challenges that lead to the failure of the current chemotherapy methods. Herein, a zero‐waste doxorubicin‐loaded heparin/folic acid/l ‐arginine (HFLA‐DOX) nanomotor with motion ability and sustained release of nitric oxide (NO) to achieve deep drug penetration and effective reversal of MDR in cancer chemotherapy is designed. The targeted recognition, penetration of blood vessels, intercellular penetration, special intracellular distribution (escaping from lysosomes and accumulating in Golgi and nucleus), 3D multicellular tumor spheroids (3D MTSs) penetration, degradation of tumor extracellular matrix (ECM), and reversal of MDR based on the synergistic effects of the motion ability and sustained NO release performance of the NO‐driven nanomotors are investigated in detail. Correspondingly, a new chemotherapy mode called recognition‐penetration‐reversal‐elimination is proposed, whose effectiveness is verified by in vitro cellular experiments and in vivo animal tumor model, which can not only provide effective solutions to these challenges encountered in cancer chemotherapy, but also apply to other therapy methods for the special deep‐tissue penetration ability of a therapeutic agent. Abstract : Deep drug penetration and effective reversal of multidrug resistance in cancer chemotherapy can be efficiently realized by motion ability and sustained release of nitric oxide (NO) by NO‐driven nanomotor.