COVID19 Drug Repository: text-mining the literature in search of putative COVID19 therapeutics. Issue Volume 49:Issue D1(2021) (9th November 2020)

• Record Type: Journal Article
• Authors: Tworowski, Dmitry; Gorohovski, Alessandro; Mukherjee, Sumit; Carmi, Gon; Levy, Eliad; Detroja, Rajesh; Mukherjee, Sunanda Biswas; Frenkel-Morgenstern, Milana
• Is Part Of: Nucleic acids research. Volume 49:Issue D1(2021)
• Page Start: D1113
• Page End: D1121
• Publication Date: 2020-11-09
• Subjects: Nucleic acids -- Periodicals; Molecular biology -- Periodicals; 572.805
• DOI: 10.1093/nar/gkaa969
• Languages: English
• ISSNs: 0305-1048

Abstract

Abstract: The recent outbreak of COVID-19 has generated an enormous amount of Big Data. To date, the COVID-19 Open Research Dataset (CORD-19), lists ∼130, 000 articles from the WHO COVID-19 database, PubMed Central, medRxiv, and bioRxiv, as collected by Semantic Scholar. According to LitCovid (11 August 2020), ∼40, 300 COVID19-related articles are currently listed in PubMed. It has been shown in clinical settings that the analysis of past research results and the mining of available data can provide novel opportunities for the successful application of currently approved therapeutics and their combinations for the treatment of conditions caused by a novel SARS-CoV-2 infection. As such, effective responses to the pandemic require the development of efficient applications, methods and algorithms for data navigation, text-mining, clustering, classification, analysis, and reasoning. Thus, our COVID19 Drug Repository represents a modular platform for drug data navigation and analysis, with an emphasis on COVID-19-related information currently being reported. The COVID19 Drug Repository enables users to focus on different levels of complexity, starting from general information about (FDA-) approved drugs, PubMed references, clinical trials, recipes as well as the descriptions of molecular mechanisms of drugs' action. Our COVID19 drug repository provide a most updated world-wide collection of drugs that has been repurposed for COVID19 treatments around the world.