Facile C−F Bond Activation Approach to FAMT‐Based Difluoromethyl‐BNCT Drug Candidates. Issue 2 (18th January 2021)
- Record Type:
- Journal Article
- Title:
- Facile C−F Bond Activation Approach to FAMT‐Based Difluoromethyl‐BNCT Drug Candidates. Issue 2 (18th January 2021)
- Main Title:
- Facile C−F Bond Activation Approach to FAMT‐Based Difluoromethyl‐BNCT Drug Candidates
- Authors:
- Yokawa, Akitaka
Hatanaka, Miho
Mikami, Koichi - Abstract:
- Abstract: Lithium 1, 3‐bis(2, 6‐diisopropylphenyl)‐1, 3, 2‐diazaborolidinyl‐2‐uide activates the C−F linkage of fluoroform (CF3 H) to provide air‐stable difluoromethylborane compounds. Computational analysis of SN 2‐type transition state for the C−F bond activation of fluoroform with boryllithium clarifies the mechanism involving the lithium dimeric species in the pre‐reaction complex. FAMT (=3‐fluoro‐l ‐α‐methyl‐tyrosine)‐based difluoromethyl‐BNCT (boron neutron capture therapy) drug candidates is thus produced by the present C−F bond activation. Abstract :
- Is Part Of:
- Helvetica chimica acta. Volume 104:Issue 2(2021)
- Journal:
- Helvetica chimica acta
- Issue:
- Volume 104:Issue 2(2021)
- Issue Display:
- Volume 104, Issue 2 (2021)
- Year:
- 2021
- Volume:
- 104
- Issue:
- 2
- Issue Sort Value:
- 2021-0104-0002-0000
- Page Start:
- n/a
- Page End:
- n/a
- Publication Date:
- 2021-01-18
- Subjects:
- BNCT drug -- boron -- boryllithium -- C−F bond activation -- difluoromethylation -- drug design -- fluoroform
Chemistry -- Periodicals
Chemistry, Analytical -- periodicals
Chimie -- Périodiques
540 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1522-2675 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/hlca.202000211 ↗
- Languages:
- English
- ISSNs:
- 0018-019X
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 4287.000000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 15781.xml