Prevalence of Myocardial Infarction in Patients With Chronic Pancreatitis. Issue 1 (January 2021)

• Record Type: Journal Article
• Authors: Khan, Danyal; Abureesh, Mohammad; Alkhayyat, Motasem; Sadiq, Waleed; Alshami, Mohammad; Munir, Abdullah B.; Karam, Boutros; Deeb, Liliane; Lafferty, James
• Is Part Of: Pancreas. Volume 50:Issue 1(2021)
• Publication Date: 2021-01
• Subjects: coronary artery disease -- chronic inflammation -- chronic pancreatitis -- myocardial infarction -- ACS - acute coronary syndrome -- CAD - coronary artery disease -- CKD - chronic kidney disease -- CP - chronic pancreatitis -- DM - diabetes mellitus -- HTN- hypertension -- MI - myocardial infarction -- OR - odds ratio -- SNOMED-CT - Systematized Nomenclature of Medicine–Clinical Terms; Pancreas -- Diseases -- Periodicals; Pancreas -- Periodicals; Neuroendocrine tumors -- Periodicals; 616.37005
• DOI: 10.1097/MPA.0000000000001721
• Languages: English
• ISSNs: 0885-3177

Abstract

Abstract : Objective: We conducted this study to ascertain whether chronic inflammation secondary to chronic pancreatitis (CP) has any association with myocardial infarction(MI). Methods: Data were collected from a commercial database (Explorys, Inc, IBM Watson, Ohio). Adults with the diagnosis of "chronic pancreatitis, " based on Systematized Nomenclature of Medicine–Clinical Terms, were included in the CP group, and the rest of the patients were included in the non-CP group. The prevalence of MI was compared in both groups, and statistical multivariate model was performed. Results: A total of 28, 842, 210 patients were included in the study. The overall prevalence of MI was 14.22% in the CP group as compared with 3.23% in the non-CP group ( P < 0.0001). In the multivariate analysis, the odds ratio (OR) for MI in CP group was 1.453 (95% confidence interval, 1.418–1.488, P < 0.0001). Hypertension was a strong predictor for MI in the CP group with an OR of 3.2 (95% confidence interval, 3.0–3.5), followed by chronic kidney disease, older than 65 years, dyslipidemia, diabetes mellitus, obesity, alcohol abuse, smoking, White race, and male sex. Conclusions: This study showed that CP is associated with comorbidities, which can increase the prevalence and OR of MI.