Systems biology based drug repositioning for development of cancer therapy. (January 2021)

• Record Type: Journal Article
• Authors: Turanli, Beste; Altay, Ozlem; Borén, Jan; Turkez, Hasan; Nielsen, Jens; Uhlen, Mathias; Arga, Kazim Yalcin; Mardinoglu, Adil
• Is Part Of: Seminars in cancer biology. Volume 68(2021)
• Page Start: 47
• Page End: 58
• Publication Date: 2021-01
• Subjects: AKR1C3 aldo-keto reductase family 1 member C3 -- AMPK AMP-activated protein kinase -- AKT protein kinase B -- CA carbonic anhydrase -- CDK2 cyclin-dependent kinase 2 -- COX-1/COX-2 cyclooxygenase 1/cyclooxygenase 2 -- EGFR epidermal growth factor receptor -- CDK7 cyclin-dependent kinase 7 -- HDAC2 histone deacetylase 2 -- HER2 human epidermal growth factor receptor 2 -- IGF-1 insulin-like growth factor 1 -- JNK Jun N-terminal kinase -- MAPK mitogen-activated protein kinase -- mTOR mammalian target of rapamycin -- NF-κB nuclear factor kappa light chain enhancer of activated B cells -- NPL4 nuclear protein localization protein 4 -- OCT2 organic cation transporter 2 -- P2×7 P2X purinoceptor 7 -- PI3K phosphoinositide 3-kinases -- PLC phospholipase C -- SGK1 serum/glucocorticoid regulated kinase 1 -- STAT3 signal transducer and activator of transcription 3 -- TOPK T-LAK cell-originated protein kinase -- YAP/TAZ yes-associated protein/transcriptional coactivator with PDZ-binding motif; Systems biology -- Cancer -- Drug repositioning -- Signature-based approaches -- Network-based approaches; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2019.09.020
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: Drug repositioning is a powerful method that can assists the conventional drug discovery process by using existing drugs for treatment of a disease rather than its original indication. The first examples of repurposed drugs were discovered serendipitously, however data accumulated by high-throughput screenings and advancements in computational biology methods have paved the way for rational drug repositioning methods. As chemotherapeutic agents have notorious side effects that significantly reduce quality of life, drug repositioning promises repurposed noncancer drugs with little or tolerable adverse effects for cancer patients. Here, we review current drug-related data types and databases including some examples of web-based drug repositioning tools. Next, we describe systems biology approaches to be used in drug repositioning for effective cancer therapy. Finally, we highlight examples of mostly repurposed drugs for cancer treatment and provide an overview of future expectations in the field for development of effective treatment strategies.