Association between insulin resistance and risk of atrial fibrillation in non-diabetics. (1st December 2020)

• Record Type: Journal Article
• Authors: Lee, Yonggu; Cha, Sung Joo; Park, Jung-Hwan; Shin, Jeong-Hun; Lim, Young-Hyo; Park, Hwan-Cheol; Shin, Jinho; Kim, Chun Ki; Park, Jin-Kyu
• Is Part Of: European journal of preventive cardiology. Volume 27:Number 18(2020)
• Page Start: 1934
• Page End: 1941
• Publication Date: 2020-12-01
• Subjects: Insulin resistance -- atrial fibrillation -- obesity -- epidemiology; Cardiovascular system -- Diseases -- Prevention -- Periodicals; Cardiac patients -- Rehabilitation -- Periodicals; 616.12
• DOI: 10.1177/2047487320908706
• Languages: English
• ISSNs: 2047-4873

Abstract

Abstract : Aims: Previous studies from Western countries have been unable to demonstrate a relationship between insulin resistance and new-onset atrial fibrillation. We aimed to evaluate this relationship in the nondiabetic Asian population. Methods: Between 2001–2003, 8175 adults (mean age 51.5 years, 53% women) without both existing atrial fibrillation and diabetes and with insulin resistance measures at baseline were enrolled and were followed by biennial electrocardiograms thereafter until 2014. We constructed multivariable-adjusted Cox proportional hazard models for risk of incident atrial fibrillation. Results: Over a median follow-up of 12.3 years, 136 participants (1.89/1000 person-years) developed atrial fibrillation. Higher homeostasis model assessment of insulin resistance (HOMA-IR) was independently associated with newly developed atrial fibrillation (hazard ratio 1.61, 95% confidence interval 1.14–2.28). Atrial fibrillation development increased at the HOMA-IR levels approximately between 1–2.5, and then plateaued afterwards ( p = 0.031). Conclusion: There is a significant relationship between insulin resistance and atrial fibrillation development independent of other known risk factors, including obesity in a nondiabetic Asian population.