Projections from the dorsomedial division of the bed nucleus of the stria terminalis to hypothalamic nuclei in the mouse. Issue 5 (3rd August 2020)

• Record Type: Journal Article
• Authors: Barbier, Marie; González, J. Antonio; Houdayer, Christophe; Burdakov, Denis; Risold, Pierre‐Yves; Croizier, Sophie
• Is Part Of: Journal of comparative neurology. Volume 529:Issue 5(2021)
• Page Start: 929
• Page End: 956
• Publication Date: 2020-08-03
• Subjects: AgRP/NPY -- anterograde and retrograde tract tracing -- dorsomedial division of the bed nucleus of the stria terminalis -- hypothalamic nuclei -- MCH -- ORX -- POMC; Comparative neurobiology -- Periodicals; Neurology -- Periodicals; 616
• DOI: 10.1002/cne.24988
• Languages: English
• ISSNs: 0021-9967

Abstract

Abstract: As stressful environment is a potent modulator of feeding, we seek in the present work to decipher the neuroanatomical basis for an interplay between stress and feeding behaviors. For this, we combined anterograde and retrograde tracing with immunohistochemical approaches to investigate the patterns of projections between the dorsomedial division of the bed nucleus of the stria terminalis (BNST), well connected to the amygdala, and hypothalamic structures such as the paraventricular (PVH) and dorsomedial (DMH), the arcuate (ARH) nuclei and the lateral hypothalamic areas (LHA) known to control feeding and motivated behaviors. We particularly focused our study on afferences to proopiomelanocortin (POMC), agouti‐related peptide (AgRP), melanin‐concentrating‐hormone (MCH) and orexin (ORX) neurons characteristics of the ARH and the LHA, respectively. We found light to intense innervation of all these hypothalamic nuclei. We particularly showed an innervation of POMC, AgRP, MCH and ORX neurons by the dorsomedial and dorsolateral divisions of the BNST. Therefore, these results lay the foundation for a better understanding of the neuroanatomical basis of the stress‐related feeding behaviors. Abstract : Neurons of the dorsomedial division of the bed nucleus of the stria terminalis (BNSTdm) project onto hypothalamic nuclei including the paraventricular (PVH), dorsomedial (DMH), arcuate (ARH) nuclei and the lateral hypothalamic area (LHA). In particular, BNSTdm neurons innervate proopiomelanocortin (POMC), agouti‐related peptide (AgRP), melanin‐concentrating hormone (MCH) and orexin (ORX) expressing neurons of the ARH and the LHA, respectively.