Base Editing Landscape Extends to Perform Transversion Mutation. Issue 12 (December 2020)

• Record Type: Journal Article
• Authors: Molla, Kutubuddin A.; Qi, Yiping; Karmakar, Subhasis; Baig, Mirza J.
• Is Part Of: Trends in genetics. Volume 36:Issue 12(2020)
• Page Start: 899
• Page End: 901
• Publication Date: 2020-12
• Subjects: base editing -- CRISPR/Cas -- transversion base editor -- point mutation -- C-to-G editing -- agriculture -- therapeutics; Genetics -- Periodicals; 576.5
• DOI: 10.1016/j.tig.2020.09.001
• Languages: English
• ISSNs: 0168-9525

Abstract

Abstract : Base editors have drawn considerable academic and industrial attention in recent years because of their ability to alter single DNA bases with precision. However, the existing cytosine and adenine base editors can only install transition mutations. Three recent studies (Kurt et al ., Zhao et al ., and Chen et al . ) expand the base editing toolbox by developing cytosine transversion base editors.