Evaluating Candida albicans biofilm formation in silkworms. (11th August 2020)

• Record Type: Journal Article
• Authors: Matsumoto, Yasuhiko; Kurakado,, Sanae; Sugita, Takashi
• Is Part Of: Medical mycology. Volume 59:Number 2(2021)
• Page Start: 201
• Page End: 205
• Publication Date: 2020-08-11
• Subjects: Candida albicans -- biofilm -- in vivo evaluation -- medical device -- silkworm; Medical mycology -- Periodicals; Veterinary mycology -- Periodicals; Mycology -- Periodicals; Mycoses -- Periodicals; Pathogenic fungi -- Periodicals; 616.969005
• DOI: 10.1093/mmy/myaa064
• Languages: English
• ISSNs: 1369-3786

Abstract

Abstract: Candida albicans is a pathogenic fungus that causes deep mycosis in immunocompromised patients and forms a biofilm on catheter surfaces. Here we showed that C. albicans infection of silkworms led to biofilm formation on the surface of polyurethane fibers, a catheter substrate material, while inside the silkworm body. Silkworms inserted with polyurethane fibers survived for at least 48 hours. When silkworms inserted with polyurethane fibers were subsequently infected with C. albicans, biofilm formed on the surface of the polyurethane fiber within 24 hours in the silkworm body. These results suggest that silkworms can be used to evaluate C. albicans biofilm formation.