Airway microbiota is associated with the severity of non‐CF bronchiectasis. (14th October 2020)
- Record Type:
- Journal Article
- Title:
- Airway microbiota is associated with the severity of non‐CF bronchiectasis. (14th October 2020)
- Main Title:
- Airway microbiota is associated with the severity of non‐CF bronchiectasis
- Authors:
- Li, Liyang
Zhang, Jiaming
Li, Zhuozhe
Zhang, Cuiping
Bi, Jing
Zhou, Jian
Song, Yuanlin
Shao, Changzhou - Abstract:
- Abstract: Background: Airway microbiota are associated with several chronic respiratory diseases. However, limited studies examined microbiota in non‐cystic fibrosis (non‐CF) bronchiectasis, especially its relationship with severity and immunology. Objectives: We characterized the microbiota of patients with different severities of bronchiectasis and examined the correlation between microbiota and the immunological indices. Materials and methods: The microbiota of 63 sputum samples from 40 patients with bronchiectasis were analyzed by 16S rRNA gene sequencing. Blood tests and related immunological indices were detected. Results: According to the baseline data of patients with bronchiectasis, we found that more severe bronchiectasis was accompanied by lower prealbumin levels. The 16S rRNA sequencing analyses demonstrated that Pseudomonas‐dominated microbiota produced lower levels of interleukin‐4 (IL‐4) and transforming growth factor‐β (TGF‐β) compared to other‐dominated microbiota. The airway microbiota of patients with mild bronchiectasis clustered apart from those of patients with severe bronchiectasis, which correlated with IL‐4 and other clinical indices. Conclusion: There are differences in the airway microbiota between patients with mild and severe bronchiectasis. The airway microbiota was related to some clinical indices that represent effects on the immune system.
- Is Part Of:
- Clinical respiratory journal. Volume 15:Number 2(2021)
- Journal:
- Clinical respiratory journal
- Issue:
- Volume 15:Number 2(2021)
- Issue Display:
- Volume 15, Issue 2 (2021)
- Year:
- 2021
- Volume:
- 15
- Issue:
- 2
- Issue Sort Value:
- 2021-0015-0002-0000
- Page Start:
- 154
- Page End:
- 162
- Publication Date:
- 2020-10-14
- Subjects:
- 16S rRNA sequencing -- immunology -- microbiota -- non‐CF bronchiectasis
Respiratory organs -- Diseases -- Periodicals
Respiratory organs -- Periodicals
616.24 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1752-699X ↗
http://www.blackwell-synergy.com/loi/CRJ ↗
http://ezproxy.aut.ac.nz/login?url=http://YU7RZ9HN8Y.search.serialssolutions.com/?V=1.0&L=YU7RZ9HN8Y&S=JCs&C=THCRJ&T=marc ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1111/crj.13279 ↗
- Languages:
- English
- ISSNs:
- 1752-6981
- Deposit Type:
- Legaldeposit
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- Available online (eLD content is only available in our Reading Rooms) ↗
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- British Library DSC - 3286.374350
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