A novel hydrogel sheet prevents postoperative pancreatic fistula in a rat model. (1st December 2020)

• Record Type: Journal Article
• Authors: Kemmochi, Akira; Tamura, Takafumi; Shimizu, Yoshio; Owada, Yohei; Ozawa, Yusuke; Hisakura, Katsuji; Oda, Tatsuya; Kawano, Yayoi; Hanawa, Takehisa; Ohkohchi, Nobuhiro
• Is Part Of: Journal of hepato-biliary-pancreatic sciences. Volume 28:Number 2(2021)
• Page Start: 192
• Page End: 201
• Publication Date: 2020-12-01
• Subjects: hydrogel -- pancreatic fistula -- polyvinyl alcohol -- postoperative pancreatic fistula; Liver -- Diseases -- Periodicals; Biliary tract -- Diseases -- Periodicals; Pancreas -- Diseases -- Periodicals; 617.556
• DOI: 10.1002/jhbp.867
• Languages: English
• ISSNs: 1868-6974

Abstract

Abstract: Aim: To evaluate the efficacy of a novel hydrogel sheet in preventing postoperative pancreatic fistula (POPF). Background: Postoperative pancreatic fistula is a life‐threatening complication. As no study has reported the use of hydrogel sheets in preventing POPF, their effectiveness for that purpose remains unclear. Methods: A novel hydrogel sheet made of polyvinyl alcohol (PVA) was prepared by the freeze‐thaw method. The pancreatic ducts and surrounding pancreatic parenchyma of rats were transected to induce a pancreatic fistula. Next, the sheet was attached to the transection site. Ascitic fluid amylase and lipase concentrations were measured. Neoveil ®, a nonwoven polyglycolic acid (PGA) felt, is already clinically used as an absorbable reinforcing material at pancreatic transection sites. Neoveil ® was used for comparison, as was VIEWGEL ®, which is marketed as a wound dressing. Results: The hydrogel sheet remained in place 48 hours postoperatively. The ascitic amylase concentrations in the control, VIEWGEL ® ‐treated, Neoveil ® ‐treated, and hydrogel‐treated rats, respectively, were 4992.4 ± 5355.7, 1068.4 ± 269.1, 730.2 ± 425.2, and 303.1 ± 240.1 IU/L; the ascitic lipase concentrations were 2279.8 ± 3395.2, 169.5 ± 100.6, 90.4 ± 71.0, and 86.8 ± 59.8 IU/L. The ascitic amylase and lipase levels were significantly lower in the hydrogel group than in the other groups ( P < .05). Conclusions: This novel hydrogel sheet effectively prevents pancreatic fistulas and has promising clinical application potential. Abstract : Highlight Kemmochi and colleagues developed a novel hydrogel sheet made of polyvinyl alcohol to prevent postoperative pancreatic fistula. Rat pancreases were transected to induce pancreatic fistula, and Viewgel®, Neoveil® or the hydrogel sheet were attached to the transected site. The hydrogel sheet showed a higher preventive effect than existing medical materials.