Enhancement of tumor lethality of ROS in photodynamic therapy. (3rd November 2020)

• Record Type: Journal Article
• Authors: Ming, Lan; Cheng, Kai; Chen, Yu; Yang, Rui; Chen, Daozhen
• Is Part Of: Cancer medicine. Volume 10:Number 1(2021)
• Page Start: 257
• Page End: 268
• Publication Date: 2020-11-03
• Subjects: hypoxia -- photodynamic therapy -- reactive oxygen species -- ROS defense system -- tumor treatment; 616.994005
• DOI: 10.1002/cam4.3592
• Languages: English
• ISSNs: 2045-7634

Abstract

Abstract: In the process of photodynamic therapy (PDT) treatment of tumors, reactive oxygen species (ROS) plays a key role in destroying tumor tissues. However, traditional PDT often has limited ROS killing capacity due to hypoxia in the tumor microenvironment (TME) or obstruction by the ROS defense system, resulting in poor efficacy. Therefore, enhancing the killing effect of ROS on tumors is the core of enhancing the anti‐tumor effect of PDT. In recent years, many studies have developed a series of strategies to enhance the ability of ROS to kill tumors in view of the limitations of the TME on PDT. This article summarizes the commonly used or innovative strategies in recent years, including not only frequently used methods for hypoxia in the TME but also innovative strategies to inhibit the ROS defense system. Abstract : In recent years, many studies have developed a series of strategies to enhance the ability of reactive oxygen species (ROS) to kill tumors in view of the limitations of the tumor microenvironment (TME) on photodynamic therapy. This article summarizes the commonly used or innovative strategies in recent years, including not only the common methods for TME hypoxia but also innovatively covering the relevant strategies for inhibiting the ROS defense system.