Cannabinoids Improve Gastrointestinal Symptoms in a Parenteral Nutrition–Dependent Patient With Chronic Intestinal Pseudo‐Obstruction. Issue 2 (17th March 2020)

• Record Type: Journal Article
• Authors: Zemrani, Boutaina; Lambe, Cécile; Goulet, Olivier
• Is Part Of: JPEN, Journal of parenteral and enteral nutrition. Volume 45:Issue 2(2021)
• Page Start: 427
• Page End: 429
• Publication Date: 2020-03-17
• Subjects: cannabinoids -- children -- intestinal failure -- parenteral nutrition; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; 615.85484
• DOI: 10.1002/jpen.1821
• Languages: English
• ISSNs: 0148-6071

Abstract

Abstract: Chronic intestinal pseudo‐obstruction (CIPO) is a rare and challenging cause of pediatric intestinal failure, requiring long‐term parenteral nutrition in most cases. Despite optimal management, some patients experience chronic abdominal pain and recurrent obstructive episodes with a major impact on their quality of life. Cannabinoids have been successfully used in some conditions. However, their use in CIPO has never been reported in the literature. We report a case of successful use of medicinal cannabinoids in a patient with CIPO, resulting in a significant reduction of abdominal pain, vomiting, and subocclusive episodes and increased appetite and weight, without major adverse events. Although further observations are required to consolidate these findings, this case may be helpful for other patients suffering from the same condition.