Developing a New Beta‐Type of Ti–Si/Sn Alloys for Targeted Orthopedic Therapeutics: Assessments of Biological Characteristics. Issue 2 (27th October 2020)

• Record Type: Journal Article
• Authors: Xin, Xirui; Yu, Hongqiang; Lv, Huixin; Ren, Jingyi; Yu, Wanqi; Ding, Xinxin; Zhou, Yanmin; Zhao, Jinghui
• Is Part Of: Advanced engineering materials. Volume 23:Issue 2(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-10-27
• Subjects: beta-type alloys -- biocompatibility -- osteogenesis -- Ti–Nb–Zr–Sn -- Ti–Nb–Zr–Ta–Si -- titanium alloys; Materials -- Periodicals; 620.11
• DOI: 10.1002/adem.202000430
• Languages: English
• ISSNs: 1438-1656

Abstract

Abstract : Titanium (Ti) alloys are widely used in tissue engineering, but their applications are limited by low strength, bactericidal properties, and metal ion release. Beta Ti alloys are promising materials for load‐bearing orthopedic implants due to their excellent corrosion resistance and high biocompatibility. Herein, developed new beta‐Ti alloys including Ti–Nb–Zr–Sn (Ti–Sn) and Ti–Nb–Zr–Ta–Si (Ti–Si) to improve structural and biochemical features of the existing Ti alloys as orthopedic implants. The new Ti–Sn and Ti–Si alloys were fabricated using mechanical ball milling and spark plasma sintering techniques respectively and compared with commercially pure Ti alloys on hydrophilicity, surface characteristics and cytotoxicity, proliferative and osteogenic differentiation effects as well as biocompatibility in human bone osteosarcoma cell line (MG63). The new beta Ti alloys showed no significant differences in proliferation and cytotoxicity on the MG63 cells. Both Ti–Sn and Ti–Si alloys, compared to the commercial pure Ti, improved the biological profile and upregulated the expressions of runt‐related transcription factor 2, osterix, and collagen mRNA levels in the MG63 cells. The Ti–Si alloy showed greater cell proliferation and osteoblastic protein expression and a better biological profile compared to the Ti and Ti–Sn alloys. The novel beta Ti alloys exhibited promising potentials in orthopedic applications. Abstract : The new beta‐titanium alloys with low elastic modulus are evaluated by multiple methods and reveal the biocompatibility of the two new titanium alloys is similar to that of pure titanium. Based on the results of MG63 osteoblast cells adhering to these materials, Ti–Si is better in osteogenesis than pure Ti or Ti–Sn.