Polymorphism and surface diversity arising from stress‐induced transformations – the case of multicomponent forms of carbamazepine. Issue 1 (25th January 2021)

• Record Type: Journal Article
• Authors: Schneider-Rauber, Gabriela; Arhangelskis, Mihails; Bond, Andrew D.; Ho, Raimundo; Nere, Nandkishor; Bordawekar, Shailendra; Sheikh, Ahmad Y.; Jones, William
• Is Part Of: Acta crystallographica. Volume 77:Issue 1(2021)
• Page Start: 54
• Page End: 67
• Publication Date: 2021-01-25
• Subjects: crystal engineering -- stress‐induced transformation -- carbamazepine -- solvate -- cocrystal -- hydrate
• DOI: 10.1107/S2052520620015437
• Languages: English
• ISSNs: 2052-5206

Abstract

Abstract : Labile multicomponent crystal forms of carbamazepine have been studied with an aim of identifying the structural and surface features that drive the outcome of thermal stress‐induced transformations. Abstract : Stress‐induced transformations of labile multicomponent organic solids may have a significant impact on industrial manufacturing processes, for example, in the pharmaceutical field. This study considers 15 carbamazepine (CBZ) multicomponent crystal forms, with the aim of identifying the structural and surface features that drive the outcome of thermal stress‐induced transformations. Analysis of the crystal structures, and specifically the degree of similarity with the CBZ polymorphs produced by desolvation‐like processes, identifies some degree of correlation between structural features. In particular, mutually exclusive supramolecular motifs identified previously within CBZ crystal structures are frequently (but not invariably) preserved, and thereby provide some indication of the anticipated polymorphic outcome. This is broadly consistent with established models relating reactant and product crystal phases. Some of the CBZ multicomponent materials show surface modifications indicative of the formation of a liquid intermediate phase, which provides an alternative dissolution/recrystallization mechanism and different polymorphic outcomes compared to the direct solid–solid transformation pathway. Other cases show intermediates of varying stoichiometry and instances of chemical decomposition. Hence, the product of thermal decomposition is frequently affected by the physical properties of the coformer, such as boiling point and reactivity. This can lead to a dependence on experimental conditions, especially when events such as recrystallization, chemical decomposition of the coformer, solubilization and peritectic melting occur concomitantly. This study highlights that the overall picture is complex, even within this series of closely related materials.