Connecting Hydroxychloroquine In Vitro Antiviral Activity to In Vivo Concentration for Prediction of Antiviral Effect: A Critical Step in Treating Patients With Coronavirus Disease 2019. (21st May 2020)

• Record Type: Journal Article
• Authors: Fan, Jianghong; Zhang, Xinyuan; Liu, Jiang; Yang, Yuching; Zheng, Nan; Liu, Qi; Bergman, Kimberly; Reynolds, Kellie; Huang, Shiew-Mei; Zhu, Hao; Wang, Yaning
• Is Part Of: Clinical infectious diseases. Volume 71:Number 12(2020)
• Page Start: 3232
• Page End: 3236
• Publication Date: 2020-05-21
• Subjects: hydroxychloroquine -- SARS-CoV-2 -- COVID-19 -- antiviral activity; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciaa623
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Translation of in vitro antiviral activity to the in vivo setting is crucial to identify potentially effective dosing regimens of hydroxychloroquine. In vitro 50%/90% maximal effective concentration values for hydroxychloroquine should be compared to the in vivo free extracellular tissue concentration, which is similar to the free plasma hydroxychloroquine concentration.