Higher pharyngeal epithelial gene expression of angiotensin-converting Enzyme-2 in patients with upper respiratory infection. (February 2021)

• Record Type: Journal Article
• Authors: Zhang, Mingjiao; Du, Lingyan; Faleti, Oluwasijibomi Damola; Huang, Jing; Xiao, Gang; Lyu, Xiaoming
• Is Part Of: International journal of infectious diseases. Volume 103(2021)
• Page Start: 378
• Page End: 380
• Publication Date: 2021-02
• Subjects: SARS-CoV-2 -- COVID-19 -- ACE2 -- Upper respiratory infection; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2020.11.197
• Languages: English
• ISSNs: 1201-9712

Abstract

Highlights: Higher ACE2 expression in the pharyngeal epithelium of patients with URI. ACE2 expression was positively correlated with the age. ACE2 expression was associated with body temperature. Abstract: We analyzed the expression of ACE2 in the pharyngeal epithelium and examined its relationship with clinical features and serological parameters in patients with upper respiratory infection (URI). The expression level of the ACE2 gene was significantly higher in patients with URI (n = 125) than in healthy control (HC) individuals (n = 52) ( p < 0.0001). The ACE2 gene expression level was significantly and positively correlated with age (r=0.1799, p = 0.0447) and body temperature (r=0.1927, p = 0.0427), which may help explain increasing coinfections with SARS-CoV-2 and other respiratory pathogens.