From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer. Issue 11 (3rd February 2021)

• Record Type: Journal Article
• Authors: Horst, Frederico Hillesheim; Rodrigues, Carime Vitória da Silva; Carvalho, Pedro Henrique Pimenta Rocha; Leite, Amanda Monteiro; Azevedo, Ricardo Bentes; Neto, Brenno A. D.; Corrêa, José Raimundo; Garcia, Mônica Pereira; Alotaibi, Saud; Henini, Mohamed; Chaves, Sacha Braun; Rodrigues, Marcelo Oliveira
• Is Part Of: RSC advances. Volume 11:Issue 11(2021)
• Page Start: 6346
• Page End: 6352
• Publication Date: 2021-02-03
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d0ra10859f
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Investigation of the immunological effect of light-up carbon-dots on cancer-bearing mice. Abstract : Bioactive carbon dots (C-dots ) with ca. 4 nm were successfully produced with singular photophysical properties, low-toxicity and interesting immunological response. The optical properties of the C-dots were investigated and the "light-up" behaviour enabled them to be explored in glucose detection and bioimaging experiments (mitochondrial selective probe). C-dots were not selective to the tumour region and several fluorescent spots were visualized spread on animal bodies. The histology investigations showed that cancer-bearing mice treated with C-dots presented a large number of regions with necrosis and inflammatory infiltrates, which were not identified for cancer-bearing mice without the treatment. These results suggested that C-dots have the potential to be explored as an immune therapy agent for melanoma skin cancer.