Relationship between detection of hepatitis B virus in saliva and periodontal disease in hepatitis B virus carriers in Japan. Issue 3 (March 2021)

• Record Type: Journal Article
• Authors: Kamimura, Hiroteru; Watanabe, Jun; Sugano, Tomoyuki; Kohisa, Junji; Abe, Hiroyuki; Kamimura, Kenya; Tsuchiya, Atsunori; Takamura, Masaaki; Okoshi, Shogo; Tanabe, Yoshinari; Takagi, Ritsuo; Nonaka, Hirofumi; Terai, Shuji
• Is Part Of: Journal of infection and chemotherapy. Volume 27:Issue 3(2021)
• Page Start: 492
• Page End: 496
• Publication Date: 2021-03
• Subjects: Hepatitis B virus -- Occult blood -- Periodontal diseases -- Horizontal infectious disease transmission; WHO World Health Organization -- HBV Hepatitis B Virus -- HBsAg Hepatitis B surface antigen -- HBeAg Hepatitis B envelope antigen -- OBI Occult HBV infection -- PCR Polymerase chain reaction -- AST Aspartate aminotransferase -- ALT Alanine aminotransferase; Chemotherapy -- Periodicals; Infection -- Periodicals; Communicable diseases -- Chemotherapy -- Periodicals; 615.5805
• DOI: 10.1016/j.jiac.2020.10.028
• Languages: English
• ISSNs: 1341-321X

Abstract

Abstract: Introduction: Although hepatitis B virus infection is well-described, the additional risk posed by oral bleeding in individuals with chronic hepatitis B virus infection has not been determined. This study aimed to determine the quantity of hepatitis B virus in the saliva of carriers in Japan, as a means of understanding the potential risk for horizontal transmission. Methods: Saliva samples from 48 confirmed hepatitis B virus carriers were included in the analysis. Hepatitis B virus concentrations and the presence of occult blood as periodontal disease were evaluated in each sample. Results: Hepatitis B surface antigen was identified in 46 of the 48 samples (98%), with hepatitis B virus DNA identified in 19 of the 48 saliva samples (40%). Occult blood was detected in 32 (67%) samples with the prevalence increasing as a function of age (r = 0.413; P = 0.003). There was a significantly positive correlation between hepatitis B virus DNA levels in the serum and saliva specimens (r = 0.895; P < 0.001). Conclusions: Occult blood in saliva was detected in most participants. The detection of hepatitis B virus DNA correlated positively with hepatitis B virus in the serum and occult blood in the saliva. Therefore, improved care of periodontal disease among older people is important for preventing horizontal transmission of hepatitis B virus.