Transient increase in blood thrombogenicity may be a critical mechanism for the occurrence of acute myocardial infarction. Issue 3 (March 2021)

• Record Type: Journal Article
• Authors: Ueda, Yasunori; Kosugi, Shumpei; Abe, Haruhiko; Ozaki, Tatsuhisa; Mishima, Tsuyoshi; Date, Motoo; Uematsu, Masaaki; Koretsune, Yukihiro
• Is Part Of: Journal of cardiology. Volume 77:Issue 3(2021)
• Page Start: 224
• Page End: 230
• Publication Date: 2021-03
• Subjects: Acute myocardial infarction -- Blood thrombogenicity -- Plaque disruption; Cardiology -- Periodicals; 616.12
• DOI: 10.1016/j.jjcc.2020.08.007
• Languages: English
• ISSNs: 0914-5087

Abstract

Highlights: Mechanism for the occurrence of acute myocardial infarction (MI) has not been clarified. Many silent plaque disruptions are detected in the coronary artery. Many vulnerable plaques may disrupt and heal without causing acute MI. Blood thrombogenicity changes dynamically due to many factors. Blood thrombogenicity increase may directly trigger the onset of acute MI. Abstract: Although the mechanism for the occurrence of acute myocardial infarction (MI) has been investigated by many pathological and clinical studies, it has not been adequately clarified yet. Although the disruption of vulnerable plaque is a well-known cause of acute MI, there are many silent plaque disruptions detected in the coronary artery by intravascular imaging studies. Therefore, many vulnerable plaques may disrupt and heal without causing acute MI. Some additional mechanisms other than the disruption of vulnerable plaque would be essential for the onset of acute MI. On the other hand, blood thrombogenicity would change dynamically due to circadian rhythms and many other factors. The combination of plaque and blood thrombogenicity would play an important and determinant role for the onset of acute MI.