Case Report: Successful Rescue Therapy of Extensively Drug-Resistant Acinetobacter baumannii Osteomyelitis With Cefiderocol. (5th May 2020)

• Record Type: Journal Article
• Authors: Dagher, Michael; Ruffin, Felicia; Marshall, Steven; Taracila, Magdalena; Bonomo, Robert A; Reilly, Rachel; Fowler, Vance G; Thaden, Joshua T
• Is Part Of: Open forum infectious diseases. Volume 7:Number 5(2020)
• Publication Date: 2020-05-05
• Subjects: Acinetobacter baumannii -- antimicrobial resistance -- cefiderocol -- osteomyelitis; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofaa150
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Cefiderocol is a novel catechol siderophore cephalosporin antibiotic developed to treat resistant gram-negative infections. We describe its successful use as rescue therapy, combined with surgical debridement, to treat a patient with osteomyelitis due to extensively drug-resistant Acinetobacter baumannii. Bacterial whole-genome sequencing identified the strain and antibiotic resistance determinants. Abstract : Cefiderocol is a novel catechol siderophore cephalosporin developed to treat resistant gram-negative infections. We report its successful use in conjunction with surgical debridement to treat osteomyelitis due to extensively drug-resistant Acinetobacter baumannii. Bacterial genome sequencing revealed the determinants of resistance.