P1066OBJECTIVIZATION OF "DRY WEIGHT" CLINICAL ASSESSMENT IN HEMODIALYSIS PATIENTS BY MULTI-FREQUENCY BIOIMPEDANCE SPECTROSCOPY WITH VECTOR ANALYSIS. (6th June 2020)

• Record Type: Journal Article
• Authors: Vishnevskii, Konstantin; Dudash, Ekaterina; Domashenko, Olga; Volkova, Olga; Turbasova, Elena; Frolova, Ekaterina
• Is Part Of: Nephrology dialysis transplantation. Volume 35(2020)Supplement 3
• Publication Date: 2020-06-06
• Subjects: Nephrology -- Periodicals; Hemodialysis -- Periodicals; Kidneys -- Transplantation -- Periodicals; Hemodialysis; Kidneys -- Transplantation; Nephrology; Periodicals; 616.61
• DOI: 10.1093/ndt/gfaa142.P1066
• Languages: English
• ISSNs: 0931-0509

Abstract

Abstract: Background and Aims: Hydration status is an important prognostic factor in patients receiving hemodialysis (HD). An accurate hydration status assessment and determination of the euvolemia ("dry weight", DW) target value is a difficult task and need to be objectified by instrumental methods. One of these methods is the vector analysis of multi-frequency bio-impedance spectroscopy (MBIS). The aim of the study was to assess the effect of DW correction according to the results of a vector analysis of MBIS on the blood pressure dynamics and the frequency of intra-dialysis complications. Method: Total 104 patients were included in the study. The mean age was 63±11 years, mean duration of renal replacement therapy was 91±68 months. Patients were randomly (block randomization) divided into the study (SG, N=52) or control (CG, N=52) groups. In the SG, the correction of DW performed according to the results of the MBIS vector analysis using the Bodystat MultiScan 5000 analyzer (Bodystat Ltd) with specially developed correction algorithm (figure ). In the CG the correction of DW was carried out only according to clinical indicators. Within 3 months before and 3 months after the initial assessment of DW the blood pressure during HD and the number of intradialytic complications were recorded in all patients. Results: In the SG, DW was increased in 13 patients by an average of 1.0±0.9 kg, decreased in 26 patients (-1.1±0.7 kg) and did not change in 13 patients. In the CG, DW increased on average by 1.3±0.9 kg in 19 patients, in 27 decreased (-1.2±0.8 kg) and in 2 did not change. In patients who had a history of increased blood pressure during dialysis, in SG the frequency of hypertension episodes decreased from 3.8 to 1.1 episodes per month (p=0.02), in contrast to CG (from 2.4 up to 2.3 episodes per month, p=0.87). Also, among patients initially prone to hypertension in SG, in contrast to CG, a decrease in systolic blood pressure was observed both before the HD (from 163±16 to 143±10 mm Hg, p=0.004) and after the HD (from 151±23 to 130±15 mmHg, p=0.02). No changes in the frequency of episodes of hypotension and diastolic blood pressure during HD were observed either in the study or in the control group Conclusion: Objectification of the dry weight clinical assessment of in HD patients using multifrequency bioimpedance spectroscopy with vector analysis can help to reduce the complications rate and arterial hypertension severity.