P0033COMPARISON OF ANXIETY, DEPRESSION AND QUALITY OF LIFE IN PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE: A CROSS-SECTIONAL, RANDOMIZED CONTROLLED PILOT STUDY. (6th June 2020)

• Record Type: Journal Article
• Authors: Ozler, Tuba Elif; Alay, Cemal; Cebeci, Egemen; Uzun, Sami; Karadag, Serhat; Ozkan, Oktay; Bashan, Yagmur; Dag, Burcu; Karaali, Zeynep; Ozturk, Savas
• Is Part Of: Nephrology dialysis transplantation. Volume 35(2020)Supplement 3
• Publication Date: 2020-06-06
• Subjects: Nephrology -- Periodicals; Hemodialysis -- Periodicals; Kidneys -- Transplantation -- Periodicals; Hemodialysis; Kidneys -- Transplantation; Nephrology; Periodicals; 616.61
• DOI: 10.1093/ndt/gfaa142.P0033
• Languages: English
• ISSNs: 0931-0509

Abstract

Abstract: Background and Aims: Patients with autosomal dominant polycystic kidney (ADPKD), in addition to uremic signs and symptoms, the need for renal replacement therapy and the risk of transferring the disease to their children put them under physical and mental stress. This may affect the psychosocial status of patients. In this study, we compared diabetic nephropathy (DN) patients who were expected to progress rapidly with early-stage ADPKD patients to reveal anxiety, depression and quality of life. Method: In our cross-sectional, randomized controlled and single-center study, 55 adult patients with early stage ADPKD with eGFR ≥ 60 ml/min/1.73 m 2 and 50 patients with DN as control group were included. Both groups were applied to state trait anxiety inventory (STAI), patient health questionnaire 9 (PHQ-9), quality of life short form 36 and Beck depression inventory in order to evaluate their depression, anxiety and quality of life. Depression, anxiety and quality of life questionnaires' results, demographic and clinical characteristics, laboratory findings of the two groups were compared. Results: Comparison of patients' and control groups demographic and clinical characteristics, and laboratory data were shown in Table 1. According to state trait anxiety inventory; moderate and high levels of anxiety were present in 94% patients with ADPKD and in 66% patients with DN (p<0.001). According to Beck depression inventory; depression is detected in 58.2% patients with ADPKD and in 26% patients with DN (p=0.001). When the PHQ-9 results were compared; depression is prevalent in 55.6% patients with ADPKD and in 34.7% patients with DN (p=0.037). Although ADPKD patients were at an early stage, we found anxiety and depression more frequent and severe than DN patients. While physical life quality was similar in both group; mental quality of life was lower in ADPKD patients according to quality of life short form 36 (p= 0.32 and p= 0.03 respectively) (Table 2). Independent variables affecting Beck depression inventory score; being a woman, smoking and being diagnosed with ADPKD; independent variables affecting PHQ9 score; being female and the excess of the number of medical tablets used daily; independent variables affecting personal trait anxiety score; being a woman, smoking, being diagnosed with ADPKDD, and presence of hypertension. Conclusion: In ADPKD patients, anxiety, depression and decrease in quality of life can be seen more frequently than other uremic patients even in the early period when renal functions are preserved. This group of patients should be evaluated in this respect from the early stages of the disease.