High-intensity interval training reduces neutrophil-to-lymphocyte ratio in persons with multiple sclerosis during inpatient rehabilitation. (June 2021)

• Record Type: Journal Article
• Authors: Joisten, Niklas; Proschinger, Sebastian; Rademacher, Annette; Schenk, Alexander; Bloch, Wilhelm; Warnke, Clemens; Gonzenbach, Roman; Kool, Jan; Bansi, Jens; Zimmer, Philipp
• Is Part Of: Multiple sclerosis. Volume 27:Number 7(2021)
• Page Start: 1136
• Page End: 1139
• Publication Date: 2021-06
• Subjects: Multiple sclerosis -- exercise -- HIIT -- NLR -- inflammation -- cellular inflammation marker -- high-intensity interval exercise -- rehabilitation; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458520951382
• Languages: English
• ISSNs: 1352-4585

Abstract

In persons with multiple sclerosis (PwMS), the neutrophil-to-lymphocyte ratio (NLR) is associated with disability status, symptomatology and disease activity. High-intensity interval training (HIIT) improves many symptoms in PwMS and may positively influence disease progression. Here, we present results from a randomized controlled trial during inpatient rehabilitation on immediate (single bout) and training (3-week intervention) effects of HIIT versus moderate continuous training on NLR and related cellular inflammation markers. Only HIIT reduced the NLR over the 3-week intervention period. These training effects might be due to repetitive inflammatory states with compensatory anti-inflammatory counterbalancing after each HIIT session.