Differential patterns of interhemispheric functional connectivity between AQP4-optic neuritis and MOG-optic neuritis: a resting-state functional MRI study. (June 2021)

• Record Type: Journal Article
• Authors: Sun, Mingming; Zhou, Huanfen; Xu, Quangang; Yang, Mo; Xu, Xintong; Zhou, Ming; Wei, Shihui
• Is Part Of: Acta radiologica. Volume 62:Number 6(2021)
• Page Start: 776
• Page End: 783
• Publication Date: 2021-06
• Subjects: Anti-aquaporin-4 antibody -- anti-myelin oligodendrocyte glycoprotein antibody -- optic neuritis -- resting-state functional magnetic resonance imaging -- voxel-mirrored homotopic connectivity -- interhemispheric functional connectivity; Radiology, Medical -- Periodicals; Radiography, Medical -- Periodicals; Radiotherapy -- Periodicals; 616.0757
• DOI: 10.1177/0284185120940250
• Languages: English
• ISSNs: 0284-1851

Abstract

Background: Several neuroimaging studies demonstrated that optic neuritis (ON) leads to functional and anatomical architecture changes in the brain. The alterations of interhemispheric functional connectivity (IFC) in patients with AQP4-ON and myelin oligodendrocyte glycoprotein (MOG)-ON are not well understood. Purpose: To investigate the differential patterns of VMHC in patients with AQP4-ON and MOG-ON. Material and Methods: Twenty-one patients with AQP4-ON, 11 patients with MOG-ON, and 34 healthy controls underwent resting-state MRI scans. One-way ANOVA was used to identify regions in which the zVMHC differed among the three groups. Post hoc two-sample t-tests were then conducted to compare zVMHC values between pairs of groups. Pearson correlation analysis was conducted to reveal relationships between mean zVMHC values and clinical variables in the AQP4-ON and MOG-ON groups. Results: The results revealed significant differences in zVMHC values in the PreCG among the three groups. Compared to the control group: the AQP4-ON group showed significantly lower VMHC values in the superior temporal gyrus, inferior frontal gyrus, and PreCG; and the MOG-ON group showed significantly higher zVMHC values in the PostCG. Compared to the AQP4-ON group, the MOG-ON group showed significantly lower zVMHC values in the PreCG/PostCG (voxel-level P <0.01, GRF correction, cluster-level P <0.05) Conclusion: Patients with AQP4-ON and those with MOG-ON showed abnormal VMHC in the motor cortices, sensorimotor cortices, and frontal lobe, possibly indicating impaired sensorimotor function in patients with ON. Moreover, differential patterns of VMHC in patients with AQP4-ON, compared to patients with MOG-ON, might serve as a clinical indicator for classification of ON.