Electrochemically induced synthesis of quinazolinones via cathode hydration of o-aminobenzonitriles in aqueous solutions. Issue 5 (15th January 2021)

• Record Type: Journal Article
• Authors: Yang, Li; Hou, Huiqing; Li, Lan; Wang, Jin; Zhou, Sunying; Wu, Mei; Ke, Fang
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 5(2020)
• Page Start: 998
• Page End: 1003
• Publication Date: 2021-01-15
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob02286a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An efficient and practical electrochemically catalyzed transition metal-free process for the synthesis of substituted quinazolinones from simple and readily available o -aminobenzonitriles and aldehydes in water has been accomplished. Abstract : An efficient and practical electrochemically catalyzed transition metal-free process for the synthesis of substituted quinazolinones from simple and readily available o -aminobenzonitriles and aldehydes in water has been accomplished. I2 /base and water play an unprecedented and vital role in the reaction. By electrochemically catalysed hydrolysis of o -aminobenzonitriles, the synthesis of quinazolinones with benzaldehyde was first proposed. The synthetic utility of this method was demonstrated by gram-scale operation, as well as the preparation of bioactive N -(2, 5-dichlorophenyl)-6-(2, 2, 2-trifluoroethoxy) pteridin-4-amine, which enables straightforward, practical and environmentally benign quinazolinone formation.