Biologic Effect of Hydrogen Sulfide and Its Role in Traumatic Brain Injury. (23rd December 2020)

• Record Type: Journal Article
• Authors: Zhang, Jiaxin; Zhang, Shaoyi; Shan, Haiyan; Zhang, Mingyang
• Other Names: Xu Shi Yuan Academic Editor.
• Is Part Of: Oxidative medicine and cellular longevity. Volume 2020(2020)
• Publication Date: 2020-12-23
• Subjects: Oxidative stress -- Periodicals; Cells -- Aging -- Periodicals; Cells -- Aging; Oxidative stress; Oxidative Stress -- Periodicals; Cell Aging -- Periodicals; Periodicals; 611.0181
• DOI: 10.1155/2020/7301615
• Languages: English
• ISSNs: 1942-0900

Abstract

Abstract : Ever since endogenous hydrogen sulfide (H2 S) was found in mammals in 1989, accumulated evidence has demonstrated that H2 S functions as a novel neurological gasotransmitter in brain tissues and may play a key role in traumatic brain injury. It has been proved that H2 S has an antioxidant, anti-inflammatory, and antiapoptosis function in the neuron system and functions as a neuroprotective factor against secondary brain injury. In addition, H2 S has other biologic effects such as regulating the intracellular concentration of Ca 2+, facilitating hippocampal long-term potentiation (LTP), and activating ATP-sensitive K channels. Due to the toxic nature of H2 S when exceeding the physiological dose in the human body, only a small amount of H2 S-related therapies was applied to clinical treatment. Therefore, it has huge therapeutic potential and has great hope for recovering patients with traumatic brain injury.