[FeFe]-Hydrogenases: maturation and reactivity of enzymatic systems and overview of biomimetic models. (11th December 2020)

• Record Type: Journal Article
• Authors: Kleinhaus, Julian T.; Wittkamp, Florian; Yadav, Shanika; Siegmund, Daniel; Apfel, Ulf-Peter
• Is Part Of: Chemical Society reviews. Volume 50:Number 3(2021)
• Page Start: 1668
• Page End: 1784
• Publication Date: 2020-12-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cs01089h
• Languages: English
• ISSNs: 0306-0012

Abstract

Abstract : [FeFe]-hydrogenases recieved increasing interest in the last decades. This review summarises important findings regarding their enzymatic reactivity as well as inorganic models applied as electro- and photochemical catalysts. Abstract : While hydrogen plays an ever-increasing role in modern society, nature has utilized hydrogen since a very long time as an energy carrier and storage molecule. Among the enzymatic systems that metabolise hydrogen, [FeFe]-hydrogenases are one of the most powerful systems to perform this conversion. In this light, we will herein present an overview on developments in [FeFe]-hydrogenase research with a strong focus on synthetic mimics and their application within the native enzymatic environment. This review spans from the biological assembly of the natural enzyme and the highly controversial discussed mechanism for the hydrogen generation to the synthesis of multiple mimic platforms as well as their electrochemical behaviour.