Photodynamic activity of Sn(iv) tetrathien-2-ylchlorin against MCF-7 breast cancer cells. Issue 6 (26th January 2021)

• Record Type: Journal Article
• Authors: Babu, Balaji; Mack, John; Nyokong, Tebello
• Is Part Of: Dalton transactions. Volume 50:Issue 6(2021)
• Page Start: 2177
• Page End: 2182
• Publication Date: 2021-01-26
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/d0dt03958f
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : The utility of Sn(iv ) tetraarylchlorins for use as photosensitizer dyes in photodynamic therapy is assessed. Abstract : A new readily-synthesized Sn(iv ) tetraarylchlorin with thien-2-yl substituents (SnC ) has been prepared and fully characterized by various spectroscopic techniques and its photophysical and photochemical properties, such as the singlet oxygen quantum yield ( Φ Δ ), fluorescence quantum yield ( Φ F ), triplet lifetime ( τ T ) and photostability, have been evaluated. SnC has an unusually high Φ Δ value of 0.89 in DMF. Studies on the photodynamic activity against MCF-7 breast cancer cells exhibited a very low IC50 value of 0.9 μM and high phototoxicity (dark versus light) indices of >27.8 after irradiation with a 660 nm Thorlabs LED (280 mW cm −2 ). The results demonstrate that Sn(iv ) tetraarylchlorins of this type are suitable candidates for further in-depth PDT studies.