A bio-inspired fluorescent nano-injectable hydrogel as a synergistic drug delivery system. (28th January 2021)

• Record Type: Journal Article
• Authors: Xu, Yue; Yang, Mingming; Ma, Qiyue; Di, Xiang; Wu, Guolin
• Is Part Of: New journal of chemistry. Volume 45:Number 6(2021)
• Page Start: 3079
• Page End: 3087
• Publication Date: 2021-01-28
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d0nj05719c
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A nano-injectable hydrogel with fluorescence properties and controlled sequential release of dual drugs. Abstract : Synergistic drug therapy has proven to be an effective strategy for various disease states. An injectable nano-hydrogel has been successfully prepared by random copolymerization of N -isopropylacrylamide (NIPAM) and acrylic functionalized nucleobase (adenine) for synergistic drug delivery. Different from ordinary polymeric hydrogels, the prepared injectable hydrogel showed a special phase-separated structure, combining nano-particles and macro-hydrogels, and potentially became useful as a dual drug carrier with a sequential release of different drug species. In addition, the obtained nanogels demonstrated fluorescence characteristics in a broad concentration range, without emission quenching at high concentrations. This feature is particularly important for possible visualization and imaging purposes. The studied material may represent a suitable candidate for fluorescent biological probes and dual drug delivery systems with intelligent responsiveness.