Delivery of siRNA by tailored cell-penetrating urea-based foldamers. Issue 12 (13th January 2021)
- Record Type:
- Journal Article
- Title:
- Delivery of siRNA by tailored cell-penetrating urea-based foldamers. Issue 12 (13th January 2021)
- Main Title:
- Delivery of siRNA by tailored cell-penetrating urea-based foldamers
- Authors:
- Bornerie, Mégane
Brion, Anaïs
Guichard, Gilles
Kichler, Antoine
Douat, Céline - Abstract:
- Abstract : Tailored end-group modifications and the formulation of cell-penetrating urea-based foldamers enable efficient siRNA delivery into cells. Abstract : Cell-penetrating foldamers (CPFs) have recently shown promise as efficient and safe nucleic acid delivery systems. However, the application of CPFs to siRNA transport remains scarce. Here, we report helical CPFs tailored with specific end-groups (pyridylthio- or n -octyl-ureas) as effective molecular systems in combination with helper lipids to intracellularly deliver biologically-relevant siRNA.
- Is Part Of:
- Chemical communications. Volume 57:Issue 12(2021)
- Journal:
- Chemical communications
- Issue:
- Volume 57:Issue 12(2021)
- Issue Display:
- Volume 57, Issue 12 (2021)
- Year:
- 2021
- Volume:
- 57
- Issue:
- 12
- Issue Sort Value:
- 2021-0057-0012-0000
- Page Start:
- 1458
- Page End:
- 1461
- Publication Date:
- 2021-01-13
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d0cc06285e ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 15713.xml