Plasma Cell–Free DNA Next-Generation Sequencing to Diagnose and Monitor Infections in Allogeneic Hematopoietic Stem Cell Transplant Patients. (16th November 2018)

• Record Type: Journal Article
• Authors: Fung, Monica; Zompi, Simona; Seng, Hon; Hollemon, Desiree; Parham, Adama; Hong, David K; Bercovici, Sivan; Dolan, Estelle; Lien, Kathy; Teraoka, Justin; Logan, Aaron C; Chin-Hong, Peter
• Is Part Of: Open forum infectious diseases. Volume 5:Number 12(2018)
• Publication Date: 2018-11-16
• Subjects: immunocompromised -- molecular diagnostics -- next-generation sequencing -- stem cell transplant; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofy301
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Allogeneic hematopoietic stem cell transplant patients are at risk for common and atypical infections. Superior diagnostics can decrease infection-related morbidity and mortality. A novel plasma cell–free DNA next-generation sequencing test detected an uncommon presentation of Chlamydia trachomatis and recurrent and metastatic complications of Staphylococcus aureus bacteremia before standard microbiology.