Computerized Memory Specificity Training (c-MeST) for major depression: A randomised controlled trial. (January 2021)

• Record Type: Journal Article
• Authors: Hallford, D.J.; Austin, D.W.; Takano, K.; Fuller-Tyszkiewicz, M.; Raes, F.
• Is Part Of: Behaviour research and therapy. Volume 136(2021)
• Publication Date: 2021-01
• Subjects: Memory specificity -- Autobiographical memory specificity -- Depression -- Major depressive episode -- Randomised controlled trial -- Overgeneral memory; Cognitive therapy -- Periodicals; Psychotherapy -- Periodicals; 616.891
• DOI: 10.1016/j.brat.2020.103783
• Languages: English
• ISSNs: 0005-7967

Abstract

Abstract: Given modest response and high relapse after treatment for Major Depressive Episodes (MDE), the development and refinement of treatments to target cognitive vulnerabilities is indicated. Memory Specificity Training (MeST) remediates deficits in recalling detailed memories of past experiences through repeated practice of autobiographical memory retrieval. This randomised controlled trial aimed to assess the efficacy of an online, computerized version of MeST (c-MeST) for MDE. Adults ( N = 245, 88.4% female; M age = 46.4) with a current MDE were randomised to the c-MeST program or wait-list control group. Significantly fewer participants in the c-MeST group, relative to control, met criteria for an MDE at one-month follow-up (35.7% c-MeST vs. 60.6% control), but not at other time-points. The c-MeST group, relative to the control group, scored significantly higher on memory specificity at all time-points following baseline ( d = 0.53–0.93), and lower on depressive symptoms at one ( d = 0.57) and three-month follow-up ( d = 0.67). Changes in memory specificity mediated the effect of c-MeST on depressive symptoms at follow-up. c-MeST can improve memory specificity and depressive symptoms in people with an MDE, and may speed the rate of recovery. Future studies can further examine the mechanisms through which this occurs. Highlights: First study of online Memory Specificity Training for Major Depression (c-MeST). c-MeST improved memory specificity and reduced depressive symptoms. Changes in memory specificity predicted changes in depressive symptoms. Few changes were found on secondary outcomes. c-MeST may be effective in online form, and head-to-head trials are indicated.