In silico and in vitro analysis of FAK/MMP signaling axis inhibition by VO-clioquinol in 2D and 3D human osteosarcoma cancer cells. Issue 12 (27th October 2020)

• Record Type: Journal Article
• Authors: Balsa, Lucia M.; Quispe, Patricia; Baran, Enrique J.; Lavecchia, Martin J.; León, Ignacio E.
• Is Part Of: Metallomics. Volume 12:Issue 12(2020)
• Page Start: 1931
• Page End: 1940
• Publication Date: 2020-10-27
• Subjects: Metals -- Physiological effect -- Periodicals; 572.51
• DOI: 10.1039/d0mt00176g
• Languages: English
• ISSNs: 1756-5901

Abstract

Abstract : The study of novel mechanisms of action of vanadium compounds is critical to elucidating the role and importance of these kinds of compounds as antitumor and antimetastatic agents. Abstract : The study of novel mechanisms of action of vanadium compounds is critical to elucidating the role and importance of these kinds of compounds as antitumor and antimetastatic agents. This work deals with in silico and in vitro studies of one clioquinol oxidovanadium(iv ) complex [VO(clioquinol)2 ], VO(CQ)2, and its regulation of FAK. In particular, we focus on elucidating the relationship of the FAK inhibition, MMP activity and antimetastatic effects of the complex in human bone cancer cells.