Sildenafil‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms: Case report with review. Issue 6 (5th July 2020)

• Record Type: Journal Article
• Authors: Gupta, Sunil K.; Sushantika, Sushantika; Abdelmaksoud, Ayman
• Is Part Of: Dermatologic therapy. Volume 33:Issue 6(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-07-05
• Subjects: drug reaction -- inflammatory disorders -- pharmacology -- pruritus -- therapysystemic; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616.5
• DOI: 10.1111/dth.13826
• Languages: English
• ISSNs: 1396-0296

Abstract

Abstract: Sildenafil is one of the commonest over the counter drugs which is orally taken by the people for sexual enhancement. It is an inhibitor of phosphodiesterase type 5 (PDE5) and results in engorgement of carpora cavernosa and help in erectile dysfunction. There are fewer adverse cutaneous drug reactions reported by sildenafil perhaps due to use of the drug without medical prescription. Here we are reporting a case of sildenafil induced hypersensitivity syndrome that is possibly the first one and reviewing the medical literature on type of adverse cutaneous drug eruption due to sildenafil and other PDE5 inhibitors.