Barbaram, a bicyclic neolactam from the root and stem of Lycium barbarum. Issue 1 (2nd January 2021)

• Record Type: Journal Article
• Authors: Lan, Ting; Xu, Wei; Xu, Tian-Qi; Xia, Zhao; Zhang, Hai-Xin; Zhan, Ya-Ping; Zhou, Guang-Xiong
• Is Part Of: Journal of Asian natural products research. Volume 23:Issue 1(2021)
• Page Start: 82
• Page End: 88
• Publication Date: 2021-01-02
• Subjects: Lycium barbarum -- Solanaceae -- root and stem -- neolactam -- ECD calculations -- anti-inflammatory activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2019.1706498
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Barbaram (1 ), a neolactam together with other five known compunds (2 –6 ) was isolated from the EtOAc-soluble fraction of an EtOH extract of the root and stem of Lycium barbarum by using silica gel, Sephadex LH-20 column chromatography and semi-preparative RP-C18 HPLC. Based on HR-TOF-MS, NMR spectral data, quantum chemistry ECD calculations and referencing to the data reported earlier, the structures of these compounds (1 –6 ) were determined, specially including the absolute configuration of the neolactam (1 ). Compounds 2 and 4 showed significant anti-inflammatory activity in LPS-induced RAW 264.7 macrophages with the IC50 values of 8.98 ± 0.57 μM, 6.68 ± 0.77 μM. Abstract :